PF-04753299

PF-04753299

CAT N°: 36502
Price:

From 49.00 41.65

PF-04753299 is an inhibitor of LpxC (IC50 = 1.37 nM), a bacterial deacetylase involved in the biosynthesis of LPS lipid A.{58957} It is selective for LpxC over a panel of 16 human matrix metalloproteinases (MMPs; Kis = >1 µM for all). PF-04753299 is active against P. aeruginosa, K. pneumoniae, E. coli, E. aerogenes, C. freundii, and A. baumannii (MIC90s = 4, 16, 2, 4, 8, and 32 µg/ml, respectively). In vivo, PF-04753299 reduces splenic bacterial burden in a mouse model of systemic P. aeruginosa infection (ED50 = 35 mg/kg).

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-hydroxy-?R-methyl-?-(methylsulfonyl)-[1,1?-biphenyl]-4-butanamide
  • Correlated keywords
    • PF04753299 Lpx C2 Pseudomonas Klebsiella Escherichia Enterobacter Citrobacter Acinetobacter
  • Product Overview:
    PF-04753299 is an inhibitor of LpxC (IC50 = 1.37 nM), a bacterial deacetylase involved in the biosynthesis of LPS lipid A.{58957} It is selective for LpxC over a panel of 16 human matrix metalloproteinases (MMPs; Kis = >1 µM for all). PF-04753299 is active against P. aeruginosa, K. pneumoniae, E. coli, E. aerogenes, C. freundii, and A. baumannii (MIC90s = 4, 16, 2, 4, 8, and 32 µg/ml, respectively). In vivo, PF-04753299 reduces splenic bacterial burden in a mouse model of systemic P. aeruginosa infection (ED50 = 35 mg/kg).

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