PD 166326

PD 166326

CAT N°: 9000988
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From 148.00 125.80

PD 166326 is a pyridopyrimidine-type inhibitor of receptor tyrosine kinases that inhibits c-abl (IC50 = 8 nM) and Bcr/Abl-dependent cell growth (IC50 = 0.4 nM).{20180,20179} In addition to targeting a select group of receptor tyrosine kinases, PD 166326 also potently inhibits c-src (IC50 = 6 nM).{20179} Orally administered PD 166326 is well tolerated and effectively blocks Bcr/Abl kinase activity in vivo.{20177} Moreover, PD 166326 affects a distinct set of kinases from those targeted by imatinib mesylate (STI571) and can reduce the growth of some imatinib-resistant cells both in vitro and in vivo in animal models of chronic myelogenous leukemia.{20179,20177,20178}

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