€615.00 €522.75
Paxillin is a focal adhesion adapter protein that facilitates the assembly of multiprotein complexes that mediate signal transduction between the extracellular matrix and actin cytoskeleton.{59175,59176,59177} It contains four LIM domains in the C-terminal region that target paxillin to focal adhesions and an N-terminal region with five LD motifs that serve as docking sites for a variety of proteins, including vinculin, focal adhesion kinase (FAK), and Src, that facilitate intracellular signal transduction.{59177} Alternative splicing of PXN generates three isoforms, ?, ?, and ?, that contain a variable N-terminus, as well as a fourth isoform, ?, that lacks the N-terminal region.{59177} Paxillin is expressed in most tissues and predominately localizes to focal adhesions on the cell membrane.{59176,59177} Upon cytokine or growth factor stimulation or cell adhesion, paxillin is phosphorylated by a variety of kinases, including FAK and ERK, providing a scaffold for signaling proteins that are involved in the formation and regulation of focal adhesions, which mediate cell migration.{59177} It is also expressed in the cytoplasm and nucleus where it regulates gene transcription. Tumor paxillin levels are increased in patients with glioblastoma multiforme (GBM) and associated with poor survival. Cayman’s Paxillin?/?/? (N-Term) Rabbit Monoclonal Antibody can be used for immunocytochemistry (ICC) and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide from the N-terminal region of human paxillin?/?/? |
| Clone | RM256 |
| Isotype | IgG |
| Application(s) | ICC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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