PAOA

PAOA

CAT N°: 22942
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PAOA is a selective histone deacetylase (HDAC) inhibitor with IC50 values of 199 and 69 nM for HDAC1 and HDAC3, respectively.{37081} It is selective for HDAC1 and HDAC3, having IC50 values greater than 1.59 ?M for HDAC2, 4, 5, 7, and 8 in a cell-free enzyme assay. In vitro, PAOA induces histone H3 and H4 hyperacetylation.{37083} PAOA improves the metabolic deficit exhibited by murine striatal cells isolated from HdhQ111 knock-in mice in a dose-dependent manner and reduces eye neurodegeneration in a D. melanogaster model of Huntington’s disease.{37081} In vivo, PAOA prevents formation of Huntingtin (Htt) protein aggregates in the brain and reduces the cognitive deficits in the N171-82Q mouse model of Huntington’s disease.{37082}

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