Palovarotene

Palovarotene

CAT N°: 28460
Price:

From 122.00 103.70

Palovarotene an orally bioavailable retinoic acid receptor ? (RAR?) agonist.{48611} It increases retinoic acid response element (RARE) activity and decreases NF-?B activity induced by IL-1? in primary mouse stromal cells in reporter assays when used at a concentration of 60 nM.{48612} Palovarotene (10 nM) inhibits activin A-induced chondrogenic and osteogenic differentiation of mouse fibro/adipogenic progenitors (FAPs) expressing a mutated form of human activin A receptor type I (ACVR1R206H).{48613} It inhibits heterotopic ossification and preserves limb movement and growth in a ACVR1R206H fibrodysplasia ossificans progressiva (FOP) mouse model.{48614} Palovarotene (1 mg/kg per day for 14 days) decreases heterotopic ossification by 50 to 60% in a rat model of traumatic blast injury.{48615}

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