Palmitoyl Ethanolamide-d4

Palmitoyl Ethanolamide-d4

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Palmitoyl ethanolamide-d4 (PEA-d4) contains four deuterium atoms at the 7, 7′, 8, and 8′ positions. It is intended for use as an internal standard for the quantification of PEA by GC- or LC-mass spectrometry. PEA is an endogenous cannabinoid found in brain, liver, and other mammalian tissues.{2415} PEA has also been isolated from egg yolk, and found to have anti-anaphylactic and anti-inflammatory activity in vitro.{1633} PEA is an endocannabinoid which has been shown to significantly elevate cyclic AMP in cells expressing peripheral cannabinoid (CB2) receptors. However, its affinity for CB2 receptors is relatively low, at about 10 µM. Central cannabinoid (CB1) receptors have no appreciable affinity for PEA.{1134}

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