p38 MAPK Inhibitor VIII

p38 MAPK Inhibitor VIII

CAT N°: 21229
Price:

From 66.00 56.10

p38 MAP kinase inhibitor VIII is an inhibitor of p38? (IC50 = 39 nM) and p38? MAP kinases with 82 and 93% inhibition, respectively, in a kinase assay when used at a concentration of 1 µM.{38865} It is selective for p38? and 38?, lacking activity at p38?, p38?, ERK1/2, and JNK1 at a concentration of 1 µM. p38 MAP kinase inhibitor VIII inhibits IL-1?, TNF-?, IL-6, IL-8, and IL-10, but not IFN-? release from human peripheral blood mononuclear cells (PBMCs; IC50s = 30, 5, 17, 4, 10, and >1,000 nM, respectively). It also decreases ear swelling in mouse models of allergic and chronic irritative contact dermatitis when administered topically at a dose of 0.5 mg/ear.

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