€615.00 €522.75
p16INK4A is a negative regulator of the cell cycle encoded by the CDKN2A gene in humans that limits cell cycle progression and promotes cellular senescence.{59614,59615} It induces cell cycle arrest at the G1 phase by binding to cyclin-dependent kinase 4 (Cdk4) or Cdk6 in the cytoplasm, inhibiting formation of the cyclin D1/Cdk4/6 complex. p16INK4A is expressed at low levels during homeostasis and is increased in response to cellular stressors, including oncogene activation and reactive oxygen species (ROS).{59615} It is regulated by a variety of transcriptional, translational, and epigenetic mechanisms, such as chromatin modifications mediated by polycomb repressive complex 1 (PRC1) and PRC2 that inhibit CDKN2A expression.{59614,59615,59616} Aberrant CDKN2A mRNA and p16INK4A protein levels have been found in tumor biopsies from patients with a variety of cancers, including colon, breast, gall bladder, or head and neck cancer.{59615} CDKN2A SNPs have been found in patients with follicular lymphoma and are associated with reduced overall survival.{59617} Cayman’s p16INK4A (C-Term) Rabbit Monoclonal Antibody (Clone RM409) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide from the C-terminal region of human p16INK4A |
| Clone | RM409 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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