Oxy<wbr/>sophocarpine

Oxysophocarpine

CAT N°: 28305
Price:

From 237.00 201.45

Oxysophocarpine is an alkaloid that has been found in S. flavescens and has diverse biological activities, including neuroprotective, anticancer, anti-inflammatory, and analgesic properties.{48497,48498,48499} It increases cell survival and decreases lactate dehydrogenase (LDH) leakage and loss of mitochondrial membrane potential in rat primary hippocampal neurons in a model of oxygen-glucose deprivation and reperfusion injury when used at concentrations of 1, 2, and 5 ?M.{48497} Oxysophocarpine (5 ?M) inhibits proliferation and reduces migration and invasion of SCC-9 and SCC-15 oral squamous cell carcinoma (OSCC) cells in vitro.{48498} It reduces tumor growth in an SCC-9 mouse xenograft model when administered at a dose of 80 mg/kg. Oxysophocarpine (40 and 80 mg/kg) inhibits xylene-induced ear swelling and carrageenan-induced paw edema in mice.{48499} It also reduces carrageenan-induced decreases in the paw withdrawal threshold and prevents carrageenan-induced increases in paw tissue levels of TNF-?, IL-1?, IL-6, and prostaglandin E2 (PGE2; Item No. 14010) in mice when administered at a dose of 80 mg/kg.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (4R,7aS,13aR,13bR,13cS)-2,3,6,7,7a,8,13,13a,13b,13c-decahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one, 4-oxide
  • Correlated keywords
    • Sophocarpidine Sophocarpidin 13,14-didehydro-Matridin-15-one Sophora neuro protective anti cancer antiinflammatory SCC9 SCC15 TNF? IL1? IL6 PGE2 PG E2
  • Product Overview:
    Oxysophocarpine is an alkaloid that has been found in S. flavescens and has diverse biological activities, including neuroprotective, anticancer, anti-inflammatory, and analgesic properties.{48497,48498,48499} It increases cell survival and decreases lactate dehydrogenase (LDH) leakage and loss of mitochondrial membrane potential in rat primary hippocampal neurons in a model of oxygen-glucose deprivation and reperfusion injury when used at concentrations of 1, 2, and 5 ?M.{48497} Oxysophocarpine (5 ?M) inhibits proliferation and reduces migration and invasion of SCC-9 and SCC-15 oral squamous cell carcinoma (OSCC) cells in vitro.{48498} It reduces tumor growth in an SCC-9 mouse xenograft model when administered at a dose of 80 mg/kg. Oxysophocarpine (40 and 80 mg/kg) inhibits xylene-induced ear swelling and carrageenan-induced paw edema in mice.{48499} It also reduces carrageenan-induced decreases in the paw withdrawal threshold and prevents carrageenan-induced increases in paw tissue levels of TNF-?, IL-1?, IL-6, and prostaglandin E2 (PGE2; Item No. 14010) in mice when administered at a dose of 80 mg/kg.

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