Ochratoxin B

Ochratoxin B

CAT N°: 16167
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Ochratoxins are mycotoxins produced by Aspergillus and Penicillium species of fungi that contaminate foods.{20560,20493} Ochratoxin A (OTA, Item No. 11439) is a chlorinated form with toxicity that targets the kidneys, causing nephropathy and renal adenomas.{20560,20493} OTB is a non-chlorinated analog of OTA that has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion.{26426,26425,26424} OTB inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 µg/ml but lacks the genotoxic activity of OTA, even at higher concentrations.{26426}

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