NSC 59984

NSC 59984

CAT N°: 19919
Price:

From 48.00 40.80

NSC 59984 is a reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells.{31961} It is reported to induce cell death in colon cancer cells (EC50 = 8.38 µM in p53-null HCT116 cells) without evident toxicity toward normal cells.{31961} NSC 59984 has been shown to induce p53 mutant protein degradation via MDM2-mediated ubiquitination.{31961}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-(4-methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-2-propen-1-one
  • Correlated keywords
    • NSC59984 p53 reactivator p73 mutant colon cell-death HCT116 protein MDM2 ubiquitination
  • Product Overview:
    NSC 59984 is a reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells.{31961} It is reported to induce cell death in colon cancer cells (EC50 = 8.38 µM in p53-null HCT116 cells) without evident toxicity toward normal cells.{31961} NSC 59984 has been shown to induce p53 mutant protein degradation via MDM2-mediated ubiquitination.{31961}

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