NSC 23005 (sodium salt)

NSC 23005 (sodium salt)

CAT N°: 23327
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From 51.00 43.35

NSC 23005 is a small molecule inhibitor of p18, as determined by an in silico screen.{38496} It promotes expansion of murine and human hematopoietic stem cells (HSCs) with an ED50 value of 5.21 nM in a single-cell in vitro culture assay using isolated murine bone marrow cells. NSC 23005 increases the number of long-term HSCs following treatment with a CDK2 inhibitor but not a CDK4/6 inhibitor, indicating that it mediates its effects by blocking p18 inhibition of CDK4/6. It increases HSC proliferation without affecting differentiation, inducing cytotoxicity, or affecting leukemia cell proliferation.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-[(cyclohexylamino)sulfonyl]-benzoic acid, monosodium salt
  • Correlated keywords
    • 6314-70-1 NSC23005 p-18 CDK- 2 4 6 CDK4 CDK6
  • Product Overview:
    NSC 23005 is a small molecule inhibitor of p18, as determined by an in silico screen.{38496} It promotes expansion of murine and human hematopoietic stem cells (HSCs) with an ED50 value of 5.21 nM in a single-cell in vitro culture assay using isolated murine bone marrow cells. NSC 23005 increases the number of long-term HSCs following treatment with a CDK2 inhibitor but not a CDK4/6 inhibitor, indicating that it mediates its effects by blocking p18 inhibition of CDK4/6. It increases HSC proliferation without affecting differentiation, inducing cytotoxicity, or affecting leukemia cell proliferation.

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