Nodakenin

Nodakenin

CAT N°: 25213
Price:

From 48.00 40.80

Nodakenin is a coumarin glucoside originally isolated from P. decursivum that has anti-inflammatory, neuroprotective, and neurogenic activities.{43146,43147,43148,43149,43150} It dose-dependently reduces LPS-induced increases in TNF-?, IL-6, and IL-1? mRNA expression and protein levels and NK-?B activity and translocation in RAW 264.7 macrophages when used at concentrations ranging from 25 to 100 µM.{43147} Nodakenin (5, 10, and 20 mg/kg) prevents airway inflammation, hyper-responsiveness, and remodeling in a mouse model of chronic asthma induced by ovalbumin.{43148} It also decreases the levels of IL-4, IL-5, IL-13, as well as matrix metalloproteinase-2 (MMP-2) and MMP-9 in bronchoalveolar lavage fluid (BALF). Nodakenin increases proliferation of neural progenitor cells in the adult mouse hippocampal dentate gyrus, increases hippocampal protein levels of AKT and glycogen synthase kinase-3? (GSK-3?), and improves learning and memory in the passive avoidance test.{43150}

We also advise you