Nobiletin

Nobiletin

CAT N°: 15421
Price:

From €66.00 €56.10

Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities.{52725,52726,52727} It reduces LPS- and IFN-?-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at concentrations of 25, 50, and 100 µM.{52725} Nobiletin decreases proliferation of A549 lung, B16/4A5 melanoma, CCRF-HSB-2 leukemia, and TGBC11TKB gastric cancer cell lines with IC50 values of 22, 18, 13, and 8.3 µM, respectively.{52726} Dietary administration of nobiletin (0.3% w/w) reduces body weight, hepatic steatosis, and plasma LDL and HDL cholesterol levels in mice fed a high-fat, high-cholesterol diet for 18 weeks.{52727} It also inhibits increases in plasma glucose levels in an intraperitoneal glucose tolerance test in the same model.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one
  • Correlated keywords
    • natural products antioxidants cancers arthritis neurosciences inflammation oxidative injury inhibitors inhibits polymethoxylated flavonoids citrus fruits peels antioxidant anti-oxidant anti oxidants anti-inflammatory antiinflammatory inflammatory cancers arthritis neurodegeneration ATP-binding cassettes ABC proteins resistance NSCs 618903 76751 NSC618903 NSC76751 NSC-618903 NSC-76751 bioavailability diseases ATP binding P-glycoprotein Ps glycoproteins breasts B-16 A-5 549
  • Product Overview:
    Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities.{52725,52726,52727} It reduces LPS- and IFN-?-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at concentrations of 25, 50, and 100 µM.{52725} Nobiletin decreases proliferation of A549 lung, B16/4A5 melanoma, CCRF-HSB-2 leukemia, and TGBC11TKB gastric cancer cell lines with IC50 values of 22, 18, 13, and 8.3 µM, respectively.{52726} Dietary administration of nobiletin (0.3% w/w) reduces body weight, hepatic steatosis, and plasma LDL and HDL cholesterol levels in mice fed a high-fat, high-cholesterol diet for 18 weeks.{52727} It also inhibits increases in plasma glucose levels in an intraperitoneal glucose tolerance test in the same model.

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