Nimesulide-d<sub>5</sub>

Nimesulide-d5

CAT N°: 33813
Price:

From 129.00 109.65

Nimesulide-d5 is intended for use as an internal standard for the quantification of nimesulide (Item No. 70640) by GC- or LC-MS. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50s = 1.27 and 0.03 µM for the human and ovine enzymes, respectively).{1364,1286} It is selective for COX-2 over COX-1 (IC50s = 70 and 22 µM for the human and ovine enzymes, respectively). Nimesulide also inhibits sodium-dependent neutral amino acid transporter (B0AT1) with an IC50 value of 23 µM for the rat kidney transporter.{58421} It inhibits infection-induced increases in brain prostaglandin E2 (PGE2; Item No. 14010) levels, as well as reduces pyresis (ED50 = 0.3 mg/kg), in yeast-infected rats.{5796} Nimesulide (2.9 mg/kg) inhibits formalin-induced hindpaw thermal hyperalgesia in rats.{58422}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-(4-nitro-2-(phenoxy-d5)phenyl)methanesulfonamide
  • Correlated keywords
    • deuterated deuterium GCMS LCMS COX2 COX1 PGE 2 antiinflammatory nonsteroidal
  • Product Overview:
    Nimesulide-d5 is intended for use as an internal standard for the quantification of nimesulide (Item No. 70640) by GC- or LC-MS. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50s = 1.27 and 0.03 µM for the human and ovine enzymes, respectively).{1364,1286} It is selective for COX-2 over COX-1 (IC50s = 70 and 22 µM for the human and ovine enzymes, respectively). Nimesulide also inhibits sodium-dependent neutral amino acid transporter (B0AT1) with an IC50 value of 23 µM for the rat kidney transporter.{58421} It inhibits infection-induced increases in brain prostaglandin E2 (PGE2; Item No. 14010) levels, as well as reduces pyresis (ED50 = 0.3 mg/kg), in yeast-infected rats.{5796} Nimesulide (2.9 mg/kg) inhibits formalin-induced hindpaw thermal hyperalgesia in rats.{58422}

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