NIH 12848

NIH 12848

CAT N°: 26035
Price:

From 55.00 46.75

NIH 12848 is an inhibitor of phosphatidylinositol 5-phosphate 4-kinase ? (PI5P4K?; IC50 = ~1 µM).{42606} It is selective for PI5P4K? over PI5P4K? and PI5P4K? (IC50s = >100 µM). NIH 12848 inhibits translocation of the Na+/K+-ATPase to the plasma membrane in mouse principal kidney cortical collecting duct (mpkCCD) cells. NIH 12848 is also an inhibitor of USP1/UAF complex deubiquitinase activity (IC50 = 7.9 µM).{42607} It increases accumulation of monoubiquitinated proliferating cell nuclear antigen (PCNA) in H1299 non-small cell lung cancer (NSCLC) cells when used at a concentration of 20 µM.

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