NFAT Activation Inhibitor III

NFAT Activation Inhibitor III

CAT N°: 21812
Price:

From 92.00 78.20

NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT).{21639} It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 µM), preventing it from binding and dephosphorylating NFAT.{21639} NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin (Item No. 10004974). It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.{21639}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 9,10-dihydro-9,10[1′,2′]-benzenoanthracene-1,4-dione
  • Correlated keywords
    • NSC25996 INCA6 triptycene-1,4-quinone dioxotriptycene triptycenoquinone
  • Product Overview:
    NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT).{21639} It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 µM), preventing it from binding and dephosphorylating NFAT.{21639} NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin (Item No. 10004974). It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.{21639}

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