Neridronic Acid

Neridronic Acid

CAT N°: 29692
Price:

From 85.00 72.25

Neridronic acid is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50 = 388.2 nM in a cell-free assay).{53519} It decreases the differentiation of RAW 264.7 cells into osteoclasts in a CRL-12257 co-culture model of osteoclastogenesis when used at concentrations ranging from 0.001 to 100 µM.{53520} Neridronic acid (30 µM) inhibits FGF2-induced proliferation and tube formation in human umbilical vein endothelial cells (HUVECs).{53521} It reduces the loss of trabeculae and increases bone density in the tibial metaphysis of growing rats when administered subcutaneously at a dose of 0.1 mg/kg per day.{53522}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • P,P?-(6-amino-1-hydroxyhexylidene)bis-phosphonic acid
  • Correlated keywords
    • 437763-00-3 6-Amino-1-Hydroxy-Hexylidene-1,1-Bisphosphonate Nerixia CRL12257 osteo-clastogenesis FGF-2 HUVEC
  • Product Overview:
    Neridronic acid is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50 = 388.2 nM in a cell-free assay).{53519} It decreases the differentiation of RAW 264.7 cells into osteoclasts in a CRL-12257 co-culture model of osteoclastogenesis when used at concentrations ranging from 0.001 to 100 µM.{53520} Neridronic acid (30 µM) inhibits FGF2-induced proliferation and tube formation in human umbilical vein endothelial cells (HUVECs).{53521} It reduces the loss of trabeculae and increases bone density in the tibial metaphysis of growing rats when administered subcutaneously at a dose of 0.1 mg/kg per day.{53522}

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