Neoandrographolide

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 3-[2-[(1R,4aS,5R,8aS)-5-[(?-D-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone
• Correlated keywords
  • diterpenoid medicinal plant immunosuppression antithrombosis anti-inflammatory antineoplastic anti-viral anti-bacterial anti-diabetic anti-oxidative stress antipyretic anti-edematogenic anti-nociceptive endothelial cell inflammation furin inhibitor anti-thrombosis antiinflammatory anti-neoplastic antiviral antibacterial antidiabetic antioxidative antiedematogenic antinociceptive immunology infectious disease intracellular signaling biochemical natural product inhibit Andrographis paniculata A. paniculata therapeutic immunosuppressant antithrombotic anti-thrombotic LPS-induced nitric oxide production NO macrophage reduce VEGF-induced proliferation human umbilical vein pro-protein convertase neoandrographiside HUVEC cancer diterpine
• Product Overview:
  Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia. Extracts from A. paniculata have been reported to exert a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities.{21112} Neoandrographolide has been shown to inhibit LPS-induced nitric oxide production in inflammatory macrophages after oral administration to mice (25 mg/kg) or by direct addition to cultured macrophages (IC50 = 35.5 µM).{28493} At 25 µM, it can reduce VEGF-induced proliferation of human umbilical vein endothelial cells.{28494} Neoandrographolide also inhibits the pro-protein convertase furin with an IC50 value of 53.5 µM.{28495}