Nemadipine A

Nemadipine A

CAT N°: 21689
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From 102.00 86.70

Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel ?1-subunit in the C. elegans genome.{38802} It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells.{38803} It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.

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