NCOR2/SMRT (human recombinant)

CAT N°: 11633
Price:

€711.00 €604.35

Nuclear receptor corepressor 2 (NcoR2) is a transcriptional corepressor that plays an essential role in the regulation of development and metabolism. Histone deacetylases (HDACs) can mediate nuclear receptor functions by forming co-repressor complexes with nuclear receptors in the absence of ligands. However, HDACs are primarily responsible for catalyzing the deacetylation of core histones. HDAC3, a class I HDAC related to the yeast HDAC Rpd, is inactive alone and requires binding with the deacetylase activation domain (DAD) of NcoR2 for activation.{14468} The deacetylation of core histones by HDACs results in the tightening of nucleosomal integrity, restriction of access to transcription factors, and the suppression of gene transcription. In addition, HDACs mediate other transcription regulatory pathways by associating with transcription factors, such as E2F, TFIIE, TFIIF, NF-?B, p300, Stat3, p53, and the retinoblastoma (Rb) protein.{14467} The modification of chromatin structure and other non-histone proteins by HDACs serves to control many complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Thus, dysregulation of HDACs, leading to an imbalance of acetylation and deacetylation, may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.{14468}

Territorial Availability: Available through Bertin Technologies only in France

  • Correlated keywords
    • epigenetics histones deacetylases transcriptional regulations corepressor co-repressor complexes metabolism HDACs HDAC3 class I HDAC yeast Rpd DAD E2F TFIIE TFIIF NF-?B p300 Stat3 p53 retinoblastoma protein Rb protein differentiation cell death angiogenesis inflammation cancers inflammatory diseases
  • Product Overview:
    Nuclear receptor corepressor 2 (NcoR2) is a transcriptional corepressor that plays an essential role in the regulation of development and metabolism. Histone deacetylases (HDACs) can mediate nuclear receptor functions by forming co-repressor complexes with nuclear receptors in the absence of ligands. However, HDACs are primarily responsible for catalyzing the deacetylation of core histones. HDAC3, a class I HDAC related to the yeast HDAC Rpd, is inactive alone and requires binding with the deacetylase activation domain (DAD) of NcoR2 for activation.{14468} The deacetylation of core histones by HDACs results in the tightening of nucleosomal integrity, restriction of access to transcription factors, and the suppression of gene transcription. In addition, HDACs mediate other transcription regulatory pathways by associating with transcription factors, such as E2F, TFIIE, TFIIF, NF-?B, p300, Stat3, p53, and the retinoblastoma (Rb) protein.{14467} The modification of chromatin structure and other non-histone proteins by HDACs serves to control many complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Thus, dysregulation of HDACs, leading to an imbalance of acetylation and deacetylation, may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.{14468}

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