NBI 35965 (mesylate)

NBI 35965 (mesylate)

CAT N°: 18524
Price:

From 145.00 123.25

Corticotropin-releasing hormone, also known as corticotropin-releasing factor (CRF) or corticoliberin, is a peptide hormone and neurotransmitter involved in the stress response. It is secreted from the hypothalamus and is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. NBI 35965 is a selective CRF receptor 1 (CRF1) antagonist with a Ki value of 4 nM.{29749,29750} It does not inhibit CRF2 (Ki = >10,000 nM).{29750} NBI 35965 inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50s = 7.1 and 6.9, respectively) and reduces CRF- and stress-induced ACTH production in vivo.{29748} In animal models of stress, NBI 35965 administration produces anxiolytic effects.{29750}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (7S)-6-(cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene, monomethanesulfonate
  • Correlated keywords
    • 268546-19-6 1782228-59-4 CRF1 CRF-1 corticotropin-releasing factor receptor 1 corticoliberin hormone NBI35965
  • Product Overview:
    Corticotropin-releasing hormone, also known as corticotropin-releasing factor (CRF) or corticoliberin, is a peptide hormone and neurotransmitter involved in the stress response. It is secreted from the hypothalamus and is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. NBI 35965 is a selective CRF receptor 1 (CRF1) antagonist with a Ki value of 4 nM.{29749,29750} It does not inhibit CRF2 (Ki = >10,000 nM).{29750} NBI 35965 inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50s = 7.1 and 6.9, respectively) and reduces CRF- and stress-induced ACTH production in vivo.{29748} In animal models of stress, NBI 35965 administration produces anxiolytic effects.{29750}

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