€768.00 €652.80
Nav1.7 is a voltage-gated sodium channel encoded by the SCN9A gene that is expressed in sensory and dorsal root ganglia neurons as well as in the superficial laminae of the spinal cord.{41708} Nav1.7 amplifies small depolarizations of the membrane and is involved in pain perception. Inactivating gene mutations for Nav1.7 are responsible for congenital insensitivity to pain, a disorder characterized by a complete lack of pain perception. Activating gene mutations for Nav1.7 are responsible for various pain-related disorders. Mutations that decrease the action potential threshold by shifting the voltage dependence and slowing deactivation lead to hyperexcitability of dorsal root ganglia neurons in inherited erythromelalgia, which is characterized by redness and burning sensations in the feet.{41709} Missense mutations that reduce fast inactivation of Nav1.7 channels lead to persistent sodium current and are associated with paroxysmal pain disorder, which affects the sacral region and face.{41710} Cayman’s Nav1.7 Monoclonal Antibody (Clone S68-6) can be used for Western blot, immunoprecipitation, and immunocytochemistry applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Mouse |
| Antigen | fusion protein amino acids 1,751-1,946 of rat Nav1.7 |
| Clone | S68-6 |
| Isotype | IgG1 |
| Application(s) | ICC, WB, IP |
| Formulation | 100 µg of protein G-purified IgG in 100 µl PBS, pH 7.4, containing 50% glycerol and 0.09% sodium azide |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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