N-Desmethylclozapine-d<sub>8</sub>

N-Desmethylclozapine-d8

CAT N°: 26027
Price:

From 162.00 137.70

N-Desmethylclozapine-d8 is intended for use as an internal standard for the quantification of N-desmethylclozapine by GC- or LC-MS. N-Desmethylclozapine is an active metabolite of the atypical antipsychotic clozapine (Item Nos. 12059 | 25779).{25512} It was originally described as an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50 = 7.1 nM in rat choroid plexus) and later as an inverse agonist using human recombinant receptors.{47099,47100} N-Desmethylclozapine is an antagonist at dopamine D4 receptors, an agonist at ?-opioid receptors, and a partial agonist at dopamine D2 and D3, M1 muscarinic acetylcholine, and 5-HT1A receptors.{47100,25512,47101} N-Desmethylclozapine (30 mg/kg) decreases exploratory locomotor activity and increases prepulse inhibiton of the acoustic startle response in mice.{47102}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 8-chloro-11-(piperazin-1-yl-2,2,3,3,5,5,6,6-d8)-5H-dibenzo[b,e][1,4]diazepine
  • Correlated keywords
    • GCMS LCMS anti-psychotic 5HT 5HT2C 5HT1A deuterated deuterium ACP-104 ACP104 Demethylclozapine
  • Product Overview:
    N-Desmethylclozapine-d8 is intended for use as an internal standard for the quantification of N-desmethylclozapine by GC- or LC-MS. N-Desmethylclozapine is an active metabolite of the atypical antipsychotic clozapine (Item Nos. 12059 | 25779).{25512} It was originally described as an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50 = 7.1 nM in rat choroid plexus) and later as an inverse agonist using human recombinant receptors.{47099,47100} N-Desmethylclozapine is an antagonist at dopamine D4 receptors, an agonist at ?-opioid receptors, and a partial agonist at dopamine D2 and D3, M1 muscarinic acetylcholine, and 5-HT1A receptors.{47100,25512,47101} N-Desmethylclozapine (30 mg/kg) decreases exploratory locomotor activity and increases prepulse inhibiton of the acoustic startle response in mice.{47102}

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