N-desmethyl Bendamustine

N-desmethyl Bendamustine

CAT N°: 27171
Price:

688.00 584.80

N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine (Item No. 23693).{49043} N-desmethyl Bendamustine is formed through demethylation of the benzimidazole ring in bendamustine by the cytochrome P450 (CYP) isoform CYP1A2. It inhibits proliferation of non-cancerous peripheral blood leukocytes (PBLs; IC50 = 45 µM) and SU-DHL-1, SU-DHL-9, and Daudi lymphoma cells (IC50s = 270, 170, and 120 µM, respectively).

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