N<sup>?</sup>-(1-Carboxyethyl)-L-lysine

N?-(1-Carboxyethyl)-L-lysine

CAT N°: 25333
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55.00 46.75

N?-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end product (AGE) produced by the reaction of methyl glyoxal with lysine residues in proteins.{27121} Protein bound, but not free, CEL binds to the receptor for AGEs (RAGE).{37679} CEL levels are elevated in the lens of diabetic patients with cataract.{37680} Long-term caloric restriction decreases CEL levels in rat heart mitochondria.{37681} It decreases glutamate uptake and secretion of S100B in rat hippocampal slices in a RAGE-independent manner when used at a concentration of 1 mM.{37682}

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