Mycophenolate Mofetil

Mycophenolate Mofetil

CAT N°: 13988
Price:

From 68.00 57.80

Mycophenolate mofetil is a prodrug form of mycophenolic acid (Item No. 21716).{37581,37582,37583} It is converted to mycophenolic acid via carboxylesterase 1 (CES1) and CES2.{57837} Mycophenolate mofetil (1 and 10 µg/ml) inhibits thymidine incorporation in primary rat aortic smooth muscle cells.{63370} In vivo, mycophenolate mofetil (12.5 mg/kg) increases the duration of transplant motor activity in a rabbit model of retroperitoneal heterotopic heart transplantation.{37581} It eliminates formation of microbleeds and hemorrhages in the cerebrum of stroke-prone spontaneously hypertensive rats when administered at a dose of 25 mg/kg.{37582} Mycophenolate mofetil (60 mg/kg) also lowers mean arterial pressure (MAP) and reduces urinary albumin excretion and glomerulosclerosis, markers of renal damage, in a mouse model of systemic lupus erythematosus (SLE).{37583}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4E-hexenoic acid, 2-(4-morpholinyl)ethyl ester
  • Correlated keywords
    • 115007-34-6 140401-05-4 RS61443 RS-61443 TMMMF TM-MMF immunology autoimmunity immunosuppression DNA synthesis transplant transplantation lupus lymphocytes prodrug pro-drug mycophenolic acids inhibitors inhibits inosine GTP RNA mycofenolatmofetil mycofenol mykofenolatmofetil cellcept
  • Product Overview:
    Mycophenolate mofetil is a prodrug form of mycophenolic acid (Item No. 21716).{37581,37582,37583} It is converted to mycophenolic acid via carboxylesterase 1 (CES1) and CES2.{57837} Mycophenolate mofetil (1 and 10 µg/ml) inhibits thymidine incorporation in primary rat aortic smooth muscle cells.{63370} In vivo, mycophenolate mofetil (12.5 mg/kg) increases the duration of transplant motor activity in a rabbit model of retroperitoneal heterotopic heart transplantation.{37581} It eliminates formation of microbleeds and hemorrhages in the cerebrum of stroke-prone spontaneously hypertensive rats when administered at a dose of 25 mg/kg.{37582} Mycophenolate mofetil (60 mg/kg) also lowers mean arterial pressure (MAP) and reduces urinary albumin excretion and glomerulosclerosis, markers of renal damage, in a mouse model of systemic lupus erythematosus (SLE).{37583}

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