MW-150

MW-150

CAT N°: 33789
Price:

From 163.00 138.55

MW-150 is an inhibitor of p38? MAPK (Ki = 101 nM).{54878} It is 6-, 10-, and 14-fold selective for p38? MAPK over the serine/threonine protein kinase NLK, p38? MAPK, and p38? MAPK, respectively, and is also selective over the enzymatically normal mutant p38? MAPKT106M. It inhibits p38? MAPK phosphorylation of the endogenous substrate MAPK-activated protein kinase 2 (MK2) in LPS-activated glia in a concentration-dependent manner and decreases the levels of IL-1? in the same cells. MW-150 (2.5 mg/kg per day, i.p.) reduces the number of errors made in the spatial reference memory version of the radial arm water maze in aged amyloid precursor protein/presenilin 1 (APP/PS1) knock-in mice as a model of Alzheimer’s disease.

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