Muscone

Muscone

CAT N°: 16067

(±)-Muscone is an odoriferous constituent of musk, a glandular secretion originally collected from the male musk deer, that has found use both in the composition of perfumes and in traditional Chinese medicine practices.{26138} (±)-Muscone has been shown to exhibit anti-inflammatory effects by reducing the expression of proinflammatory cytokines both in vitro and in vivo. In a model of vertebral end-plate degeneration, 25 µM (±)-muscone was shown to reverse IL-1?-induced upregulation of IL-1?, TNF-?, cyclooxygenase 2, inducible nitric oxide synthase, matrix metalloproteinase 13, aggrecanase 2, and nitric oxide.{26139} It has also been reported to be both cardioprotective and neuroprotective during conditions of ischemia and to promote proliferation and differentiation of neural stem cells.{26142,26140,26141}

Territorial Availability: Available through Bertin Technologies only in France

Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.

Special Advice: Dangerous Good in said quantity, not available for sale.

  • Synonyms
    • 3-methyl-cyclopentadecanone
  • Correlated keywords
    • 956-?82-?1 22460-?48-?6 Chinese medicines musk odorant anti-inflammatory anti inflammatory inflammation antiinflammatory stems cells differentiation cardioprotection neuroprotection odoriferous expressions proinflammatory cytokines in vitro vivo ischemia proliferation natural neurosciences cardiology research methylcyclopentadecanone moschus ketones dl-muscone dl IL-1.beta. IL1B IL-1B IL1? TNF? TNF-.alpha. TNF.alpha. TNF-a TNFa exhibits cardioprotective COX2 COX 2 cyclooxygenase
  • Product Overview:
    (±)-Muscone is an odoriferous constituent of musk, a glandular secretion originally collected from the male musk deer, that has found use both in the composition of perfumes and in traditional Chinese medicine practices.{26138} (±)-Muscone has been shown to exhibit anti-inflammatory effects by reducing the expression of proinflammatory cytokines both in vitro and in vivo. In a model of vertebral end-plate degeneration, 25 µM (±)-muscone was shown to reverse IL-1?-induced upregulation of IL-1?, TNF-?, cyclooxygenase 2, inducible nitric oxide synthase, matrix metalloproteinase 13, aggrecanase 2, and nitric oxide.{26139} It has also been reported to be both cardioprotective and neuroprotective during conditions of ischemia and to promote proliferation and differentiation of neural stem cells.{26142,26140,26141}

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