Muscone

Muscone

CAT N°: 16067
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(±)-Muscone is an odoriferous constituent of musk, a glandular secretion originally collected from the male musk deer, that has found use both in the composition of perfumes and in traditional Chinese medicine practices.{26138} (±)-Muscone has been shown to exhibit anti-inflammatory effects by reducing the expression of proinflammatory cytokines both in vitro and in vivo. In a model of vertebral end-plate degeneration, 25 µM (±)-muscone was shown to reverse IL-1?-induced upregulation of IL-1?, TNF-?, cyclooxygenase 2, inducible nitric oxide synthase, matrix metalloproteinase 13, aggrecanase 2, and nitric oxide.{26139} It has also been reported to be both cardioprotective and neuroprotective during conditions of ischemia and to promote proliferation and differentiation of neural stem cells.{26142,26140,26141}

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