Mubritinib

Mubritinib

CAT N°: 12096
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Mubritinib is a selective inhibitor of the human epidermal growth factor receptor 2 (HER2), inhibiting HER2 phosphorylation with an IC50 value of 6 nM.{21787} It is without effect on EGFR, FGFR, PDGFR, JAK1, Src, and Blk (IC50 > 25 ?M).{21787} Mubritinib inhibits the proliferation of breast, bladder, kidney, and prostate cancer cells in vitro and in vivo.{21787,21788}

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