€755.00 €641.75
mTORC1 is a protein complex composed of the serine/threonine kinase mammalian target of rapamycin (mTOR), TOR complex subunit LST8 (mLST8), regulatory-associated protein of mTOR (Raptor), proline-rich Akt substrate 40 kDa (PRAS40), and DEP domain-containing mTOR-interacting protein (Deptor) that functions as a nutrient sensor and regulates cell growth and metabolism.{59623,59622,59621} PRAS40 and Deptor act as negative regulators of mTORC1 activity, and mLST8 and Raptor as scaffold proteins for substrates such as 4E-BP1 and p70 ribosomal S6 kinase 1 (p70S6K1). mTORC1 localizes to the plasma membrane, lysosome, and nucleus depending on its upstream activation signal, which include AMPK, PI3K, and Akt.{60957,59623} Activation of mTORC1 is influenced by growth factors, energy status, oxygen levels, and amino acid availability and is involved in a wide variety of processes, including aging, autophagy, stem cell and immune function, cellular senescence, and protein translation.{59623,59620,45403,59621} Dysregulation of the mTOR signaling pathway is associated with various pathologies, including cancer, rheumatoid arthritis, epilepsy, neurodegenerative diseases, and diabetes.{59623,59624,59621} Cayman’s mTOR/mLST8/Raptor Complex (human, recombinant) protein can be used for enzyme activity assays.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Insect cells |
| Formulation | 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 80 ng/µl DYKDDDDK peptide, and 20% glycerol |
| Purity | ≥58% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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