MS023 (hydro<wbr>chloride)

MS023 (hydrochloride)

CAT N°: 18361
Price:

From €85.00 €72.25

MS023 is an inhibitor of type I protein arginine methyltransferases (PRMTs; IC50s = 30, 119, 83, 4, and 5 nM for PRMT1, -3, -4, -6, and -8, respectively).{30648} It is selective for these type I PRMTs over PRMT5, -7, and -9, as well as a panel of 25 protein lysine methyltransferases (PKMTs) and DNA methyltransferases (DNMTs) when used at a concentration of 10 µM. It inhibits the methylation of histone 4 at arginine 3 (H4R3) in MCF-7 breast cancer cells (IC50 = 9 nM) and H3R2 in HEK293 cells (IC50 = 56 nM). MS023 (20 µM) also inhibits the methylation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein and the replication of SARS-CoV-2 in Vero E6 cells.{63214} It reduces tumor growth in a Huh7 mouse xenograft model when administered at a dose of 160 mg/kg.{63215}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N1-methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine, trihydrochloride
  • Correlated keywords
    • 1831110-54-3 MS-023 MS-23 MS23 PRMT3 PRMT4 PRMT6 PRMT8 PRMT7 PRMT9 MCF7 HEK-293 COVID19 SARSCoV2 SARS-CoV2 SARSCoV VeroE6 Huh-7
  • Product Overview:
    MS023 is an inhibitor of type I protein arginine methyltransferases (PRMTs; IC50s = 30, 119, 83, 4, and 5 nM for PRMT1, -3, -4, -6, and -8, respectively).{30648} It is selective for these type I PRMTs over PRMT5, -7, and -9, as well as a panel of 25 protein lysine methyltransferases (PKMTs) and DNA methyltransferases (DNMTs) when used at a concentration of 10 µM. It inhibits the methylation of histone 4 at arginine 3 (H4R3) in MCF-7 breast cancer cells (IC50 = 9 nM) and H3R2 in HEK293 cells (IC50 = 56 nM). MS023 (20 µM) also inhibits the methylation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein and the replication of SARS-CoV-2 in Vero E6 cells.{63214} It reduces tumor growth in a Huh7 mouse xenograft model when administered at a dose of 160 mg/kg.{63215}

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