MRTX-1133

MRTX-1133

CAT N°: 36413
Price:

From 117.00 99.45

MRTX-1133 is an inhibitor of K-RasG12D, a mutant form of K-Ras that accumulates in cancer cells.{62692} It selectively reduces ERK phosphorylation in AsPC-1 cells expressing mutant K-RasG12D (IC50 = 10.8 nM) over MiaPaCa-2 and SW620 cells expressing mutant K-RasG12C or K-RasG12V (IC50s = 456 and 4,400 nM, respectively) and MCF-7 cells expressing wild-type K-Ras in which ERK phosphorylation was not reduced.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-naphthalenol
  • Correlated keywords
    • MRTX1133 KRAS AsPC1 SW-620 MiaPaCa2 AsPC1 MCF7
  • Product Overview:
    MRTX-1133 is an inhibitor of K-RasG12D, a mutant form of K-Ras that accumulates in cancer cells.{62692} It selectively reduces ERK phosphorylation in AsPC-1 cells expressing mutant K-RasG12D (IC50 = 10.8 nM) over MiaPaCa-2 and SW620 cells expressing mutant K-RasG12C or K-RasG12V (IC50s = 456 and 4,400 nM, respectively) and MCF-7 cells expressing wild-type K-Ras in which ERK phosphorylation was not reduced.

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