Moguisteine

Moguisteine

CAT N°: 30362
Price:

From 48.00 40.80

Moguisteine is a peripherally acting antitussive agent.{49654,49655} It inhibits the citric acid-induced cough reflex in conscious guinea pigs but not the cough reflex induced by electrical stimulation of the afferent superior laryngeal nerve in anesthetized guinea pigs (ED50s = 5.5 and >20 mg/kg, respectively).{49655} Moguisteine (75 and 150 mg/kg, p.o.) prevents bronchoalveolar lavage fluid (BALF) eosinophil and neutrophil infiltration in an ovalbumin-sensitized guinea pig model of allergic airway inflammation.{49656} It inhibits increases in tracheal and bronchial plasma exudation induced by cigarette smoke in anesthetized guinea pigs when administered at a dose of 30 mg/kg.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-[(2-methoxyphenoxy)methyl]-?-oxo-3-thiazolidinepropanoic acid, ethyl ester
  • Correlated keywords
    • 161364-62-1 anti tussive BBR2173
  • Product Overview:
    Moguisteine is a peripherally acting antitussive agent.{49654,49655} It inhibits the citric acid-induced cough reflex in conscious guinea pigs but not the cough reflex induced by electrical stimulation of the afferent superior laryngeal nerve in anesthetized guinea pigs (ED50s = 5.5 and >20 mg/kg, respectively).{49655} Moguisteine (75 and 150 mg/kg, p.o.) prevents bronchoalveolar lavage fluid (BALF) eosinophil and neutrophil infiltration in an ovalbumin-sensitized guinea pig model of allergic airway inflammation.{49656} It inhibits increases in tracheal and bronchial plasma exudation induced by cigarette smoke in anesthetized guinea pigs when administered at a dose of 30 mg/kg.

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