ML-<wbr/>216

ML-216

CAT N°: 15186
Price:

From 48.00 40.80

. Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom’s Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 ?M) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ? 50 ?M).{24550} At 25-50 ?M, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.{24550}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[4-fluoro-3-(trifluoromethyl)phenyl]-N’-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]-urea
  • Correlated keywords
    • molecular libraries initiatives inhibitors inhibits inhibitions Blooms helicase BLM DNA damages DNA repairs enzymes cancers Bloom’s Syndromes SID-104222021 SID104222021 SIDs 104222021 CIDs 49852229 CID-49852229 CID49852229 MLs 216 ML216 helicases RECQ1 RECQ-1 RECQ one 1 RECQ5 RECQ-5 5 five E. coli UvrD PSNF5 PSNF-5 PSNFs fibroblasts cells
  • Product Overview:
    . Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom’s Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 ?M) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ? 50 ?M).{24550} At 25-50 ?M, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.{24550}

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