ML-211

ML-211

CAT N°: 17630
Price:

From 55.00 46.75

Lysophospholipase 1 (LYPLA1) is a protein palmitoyl thioesterase responsible for depalmitoylation of the oncogene HRas.{17771,28661} Palmitoylation of such oncogenes is thought to be required for trafficking and malignant transformation, making LYPLA1 a target for downregulating oncogenic signaling.{17771,28661} ML-211 is a carbamate-based dual inhibitor of LYPLA1 (IC50 = 17 nM) and the related LYPLA2 (IC50 = 30 nM).{28662} It can also inhibit the serine hydrolase ABHD11 with an IC50 value of 10 nM but is ? 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases.{28662}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • [4-(1,1-dimethylethyl)-1-piperidinyl][4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]-methanone
  • Correlated keywords
    • lysophospholipase 1 2 inhibitor biochemical cancer intracellular signaling phospholipase ML211 ML 211 protein lipidation
  • Product Overview:
    Lysophospholipase 1 (LYPLA1) is a protein palmitoyl thioesterase responsible for depalmitoylation of the oncogene HRas.{17771,28661} Palmitoylation of such oncogenes is thought to be required for trafficking and malignant transformation, making LYPLA1 a target for downregulating oncogenic signaling.{17771,28661} ML-211 is a carbamate-based dual inhibitor of LYPLA1 (IC50 = 17 nM) and the related LYPLA2 (IC50 = 30 nM).{28662} It can also inhibit the serine hydrolase ABHD11 with an IC50 value of 10 nM but is ? 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases.{28662}

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