ML-<wbr/>030

ML-030

CAT N°: 15169
Price:

From 66.00 56.10

Type 4 cyclic nucleotide phosphodiesterases (PDE4s), which are highly expressed in neutrophils and monocytes, selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. Inhibition of PDE4 activity has been examined in the context of treating asthma, chronic obstructive pulmonary disease, and as a general modulator of inflammation. ML-030 is a triazolothiadiazine that inhibits PDE4 in a cell-based cyclic nucleotide-gated cation channel biosensor assay with an EC50 value of 18.7 nM.{24535,24536} Among the PDE4 isoforms, ML-030 displays selectivity for inhibiting PDE4A (IC50 = 6.7 nM) over PDE4B1, PDE4B2, PDE4C1, and PDE4D2 (IC50 = 48.2, 37.2, 452, and 49.2 nM, respectively).{24535,24536}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine
  • Correlated keywords
    • molecular libraries Initiative library phosphodiesterases PDE4 inhibitors inhibits inhibitions neutrophils monocytes inflammation cAMPs asthma chronic obstructive pulmonary diseases COPD anti-inflammatory PDE4A anti inflammatory antiinflammatory PDE-4A MLs 030 ML-30 ML030 ML30 triazolothiadiazine PDE-4 PDEs cell-based cells based cyclics nucleotides gated nucleotide-gated cation channels biosensor assays isoforms selective allergy asthma
  • Product Overview:
    Type 4 cyclic nucleotide phosphodiesterases (PDE4s), which are highly expressed in neutrophils and monocytes, selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. Inhibition of PDE4 activity has been examined in the context of treating asthma, chronic obstructive pulmonary disease, and as a general modulator of inflammation. ML-030 is a triazolothiadiazine that inhibits PDE4 in a cell-based cyclic nucleotide-gated cation channel biosensor assay with an EC50 value of 18.7 nM.{24535,24536} Among the PDE4 isoforms, ML-030 displays selectivity for inhibiting PDE4A (IC50 = 6.7 nM) over PDE4B1, PDE4B2, PDE4C1, and PDE4D2 (IC50 = 48.2, 37.2, 452, and 49.2 nM, respectively).{24535,24536}

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