MK2 Inhibitor IV

MK2 Inhibitor IV

CAT N°: 14399
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From 122.00 103.70

Activation of the p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2) pathway has been implicated in promoting pro-inflammatory cytokine production and related inflammatory diseases. MK2 inhibitor IV is a highly selective, non-ATP competitive MK2 inhibitor with an IC50 value of 0.11 ?M.{22830} MK2 inhibitor IV has been shown to inhibit pro-inflammatory cytokine secretion from the human THP-1 acute monocytic leukemia cell line, causing inhibition of LPS-stimulated TNF-? (IC50 = 4.4 ?M) and IL-6 (IC50 = 5.2 ?M) secretion.{22830} It can also inhibit IL-1?-stimulated matrixmetalloprotease 13 secretion from the SW1353 chondrosarcoma cell line (IC50 = 5.7 ?M) and human primary chondrocyte cultures (IC50 = 2.2 ?M).{22830}

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