MK-571

MK-571

CAT N°: 10029
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From 48.00 40.80

MK-571 is a selective, orally active CysLT1 receptor antagonist.{1501} It blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively, which is indicative of CysLT1 receptor-mediated activity in these preparations.{1501} MK-571 effectively blocks LTD4 activation of recombinant human and murine CysLT1 receptors{7174,10167} but is ineffective at blocking LTC4 or LTD4 activation of the recombinant human or murine CysLT2 receptors.{10167,8519}

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