Mirabegron

Mirabegron

CAT N°: 17319
Price:

From 55.00 46.75

Mirabegron is an agonist of the ?3-adrenergic receptor (?3-AR).{28306} It induces cAMP accumulation in CHO cells expressing the ?3-AR but not the ?1- or ?2-AR (EC50s = 0.0224, >10, and >10 µM, respectively). Mirabegron reduces contraction induced by carbamoylcholine (Item No. 14486) of isolated rat and human bladder strips (EC50s = 5.1 and 0.78 µM, respectively). It decreases the frequency of isovolumetric rhythmic bladder contractions in anesthetized rats when administered at a dose 3 mg/kg. Formulations containing mirabegron have been used in the treatment of overactive bladder.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide
  • Correlated keywords
    • 928324-05-4 YM178 Betanis Betmiga (R)-Myrbetriq ?3AR ?1AR ?2AR
  • Product Overview:
    Mirabegron is an agonist of the ?3-adrenergic receptor (?3-AR).{28306} It induces cAMP accumulation in CHO cells expressing the ?3-AR but not the ?1- or ?2-AR (EC50s = 0.0224, >10, and >10 µM, respectively). Mirabegron reduces contraction induced by carbamoylcholine (Item No. 14486) of isolated rat and human bladder strips (EC50s = 5.1 and 0.78 µM, respectively). It decreases the frequency of isovolumetric rhythmic bladder contractions in anesthetized rats when administered at a dose 3 mg/kg. Formulations containing mirabegron have been used in the treatment of overactive bladder.

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