MIRA-<wbr/>1

MIRA-1

CAT N°: 14858
Price:

From 159.00 135.15

MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 µM in vitro).{30490} Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner.{30490} At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone (Item No. 11015), arrested tumor growth in a mouse xenograft model of multiple myeloma.{30491}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-[(1-oxopropoxy)methyl]-1H-pyrrole-2,5-dione
  • Correlated keywords
    • mutant reactivator re-activator p-53 MIRA1 NSC19630 N-(propionyloxymethyl)maleimide maleimidomethyl ester propionic acid WRN helicase inhibitor p53 activator VIII maleimide-derived werner syndrome
  • Product Overview:
    MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 µM in vitro).{30490} Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner.{30490} At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone (Item No. 11015), arrested tumor growth in a mouse xenograft model of multiple myeloma.{30491}

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