Milbemycin A<sub>4</sub> oxime

Milbemycin A4 oxime

CAT N°: 27938
Price:

From 473.00 402.05

Milbemycin A4 oxime is a derivative of milbemycin A4 (Item No. 17155) and a component of milbemycin oxime (Item No. 17164), compounds that both have insecticidal and nematocidal activity.{49156,49157} Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs.{49158} It inhibits the growth of clinical isolates of C. glabrata with MIC80 values ranging from 16 to greater than 32 ?g/ml.{49156} Milbemycin A4 oxime (2.5 ?g/ml) blocks efflux of fluconazole (Item No. 11594) from a clinical isolate of C. glabrata, but not from a strain lacking the efflux pumps CgCDR1 and PDH1, and reduces the MICs of fluconazole and 4-nitroquinoline 1-oxide in wild-type C. glabrata. It enhances adriamycin-induced inhibition of cell growth, as well as increases the intracellular accumulation of adriamycin and the P-glycoprotein substrate rhodamine 123 (Item No. 16672), in adriamycin-resistant, but not -sensitive, MCF-7 breast cancer cells in a concentration-dependent manner.{49159}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (6R,25R)-5-demethoxy-28-deoxy-6,28-epoxy-25-ethyl-5-(hydroxyimino)-milbemycin B
  • Correlated keywords
    • 124900-77-2 142407-33-8 A-4 CgCDR-1 PDH-1 MCF7 Candida Dirofilaria Ketomilbemycin oxomilbemycin keto-oxo 1oxide intra-cellular
  • Product Overview:
    Milbemycin A4 oxime is a derivative of milbemycin A4 (Item No. 17155) and a component of milbemycin oxime (Item No. 17164), compounds that both have insecticidal and nematocidal activity.{49156,49157} Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs.{49158} It inhibits the growth of clinical isolates of C. glabrata with MIC80 values ranging from 16 to greater than 32 ?g/ml.{49156} Milbemycin A4 oxime (2.5 ?g/ml) blocks efflux of fluconazole (Item No. 11594) from a clinical isolate of C. glabrata, but not from a strain lacking the efflux pumps CgCDR1 and PDH1, and reduces the MICs of fluconazole and 4-nitroquinoline 1-oxide in wild-type C. glabrata. It enhances adriamycin-induced inhibition of cell growth, as well as increases the intracellular accumulation of adriamycin and the P-glycoprotein substrate rhodamine 123 (Item No. 16672), in adriamycin-resistant, but not -sensitive, MCF-7 breast cancer cells in a concentration-dependent manner.{49159}

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