€474.00 €402.90
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine encoded by the MIF gene.{45618} It is released from white blood cells upon stimulation by bacterial antigens or glucocorticoids and from the anterior pituitary in response to trauma. MIF binds to CD74 receptors on macrophages, lymphocytes, dendritic, and endothelial cells and stimulates expression and secretion of the pro-inflammatory cytokines TNF-?, IFN-?, IL-1?, IL-6, and IL-8, as well as COX-2, chemokine (C-C motif) ligand 2 (CCL2), and nitric oxide. MIF knockdown is protective against LPS-induced shock and MIF pro-inflammatory signaling is positively correlated with arthritis, colitis, and systemic inflammatory response syndrome (SIRS), which is associated with cardiovascular surgery, sepsis, and injury-mediated multiple organ dysfunction syndrome (MODS).{45618,24687} MIF is overexpressed in a variety of human cancers, including pancreatic, prostate, breast, colon, brain, lung, and skin, and has been shown to promote hypoxia-induced HIF-1? stabilization leading to changes in the tumor microenvironment and stimulation of angiogenesis and neovascularization.{24686} MIF is also an enzymatically active keto-enol tautomerase that is inhibited by isothiocyanates such as sulforaphane.{24684} Cayman’s MIF Polyclonal Antibody can be used for ELISA and Western blot applications. The antibody recognizes MIF at 12.5 kDa from human samples.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 500 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Full-length recombinant human MIF protein |
| Application(s) | ELISA, WB |
| Formulation | 500 µl of protein A-purified polyclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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