Metoprolol (succinate)

Metoprolol (succinate)

CAT N°: 15429
Price:

From 176.00 149.60

Metoprolol is a potent and selective ?1-adrenergic receptor blocker (Ki = 47 nM for the ?1 receptor, compared with 3.0 and 10 ?M for the ?2 and ?3 receptors, respectively).{25395,25151} This product is a racemic mixture of enantiomers that differ in their in vivo actions and metabolism.{25396} Metoprolol is predominantly metabolized by the cytochrome P450 (CYP) isoform CYP2D6, an enzyme with significant genetic heterogeneity in function.{25396,25398} The succinate salt of metoprolol is used in formulations intended for extended release of the compound.{25397} Beta-blockers, including metoprolol, have diverse applications in cardiology and vascular disease.{25397}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • butanedioic acid, compd. with 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol (1:2)
  • Correlated keywords
    • 207983-04-8 51384-51-1 37350-?58-?6 54163-?88-?1 122404-?82-?4 1149342-?75-?5 98418-47-4 b1-adrenergic racemic P450 CYPs isoforms CYP2D6 Beloc-Zok Betaloc CR Betazok H 93/26 succinate Metoprolol Seloken Selozok Toprol XL
  • Product Overview:
    Metoprolol is a potent and selective ?1-adrenergic receptor blocker (Ki = 47 nM for the ?1 receptor, compared with 3.0 and 10 ?M for the ?2 and ?3 receptors, respectively).{25395,25151} This product is a racemic mixture of enantiomers that differ in their in vivo actions and metabolism.{25396} Metoprolol is predominantly metabolized by the cytochrome P450 (CYP) isoform CYP2D6, an enzyme with significant genetic heterogeneity in function.{25396,25398} The succinate salt of metoprolol is used in formulations intended for extended release of the compound.{25397} Beta-blockers, including metoprolol, have diverse applications in cardiology and vascular disease.{25397}

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