24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Methylnaltrexone is a quaternary positively-charged form of naltrexone (Item No. 15520) that does not cross the blood brain barrier. It is a peripherally restricted µ-opioid receptor antagonist with a Ki value of 10 nM for human recombinant receptors expressed in CHO-K1 cells and IC50 values of 130.7 and 0.43 nM in rat brain membranes prepared with sodium chloride or water, respectively.{41513} Methylnaltrexone is selective for µ-opioid receptors over ?- and ?-opioid receptors (Kis = 630.95 and 31.62 nM, respectively). It inhibits contractions evoked by electrical field stimulation (EFS) in ileum isolated from morphine-naïve guinea pigs and dose-dependently decreases spontaneous mechanical activity in ileum isolated from morphine-treated guinea pigs when administered at doses of 1 and 10 µM.{41514} It does not inhibit heroin self-administration in rats and does not induce withdrawal syndrome in morphine-dependent rhesus monkeys when administered at doses up to 32 mg/kg.{41513,41515} Formulations containing methylnaltrexone have been used in the treatment of opioid-induced constipation.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 73232-52-7 |
| Molecular formula | C21H26NO4 • Br |
| Smiles | O[C@]12[C@]3(CC[N@+](CC4CC4)(C)[C@@H]2C5)[C@](OC6=C3C5=CC=C6O)([H])C(CC1)=O.[Br-] |
| Molecular weight | 436,3 |
| Custom code | 2907.19 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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