Mepyramine (maleate)

Mepyramine (maleate)

CAT N°: 20978
Price:

From 48.00 40.80

Mepyramine is a first generation antihistamine that acts as an inverse agonist at the histamine H1 receptor. It is reported to bind with high affinity to a Gq/11 protein-coupled form of the receptor and to promote a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling of the endogenously expressed receptor, as well as to reduce G protein availability for other non-related receptors associated with this signaling pathway.{32838} Mepyramine has been shown to inhibit histamine-induced inositol phosphate production with a log EC50 value of -7.94.{32838}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N1-[(4-methoxyphenyl)methyl]-N2,N2-dimethyl-N1-2-pyridinyl-1,2-ethanediamine, 2Z-butenedioate
  • Correlated keywords
    • 5572-06-5 91-84-9 110-16-7 antihistamine anti-histamine H1 H-1 inverse AH anisopyradamine antamine anthisan antihist antisan diaminide enrumay histalet-forte histalon histan histapyran histatex histavet-p minihist NSC3604 neo-antergan neoantergan paramal paraminyl parmal prefrin-a pymafed pyra-maleate pyramaleate pyramal pyranilamine pyraninyl pyranisamine pyrilamine renstamin stamine stangen statomin thylogen
  • Product Overview:
    Mepyramine is a first generation antihistamine that acts as an inverse agonist at the histamine H1 receptor. It is reported to bind with high affinity to a Gq/11 protein-coupled form of the receptor and to promote a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling of the endogenously expressed receptor, as well as to reduce G protein availability for other non-related receptors associated with this signaling pathway.{32838} Mepyramine has been shown to inhibit histamine-induced inositol phosphate production with a log EC50 value of -7.94.{32838}

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