Mepenzolate (bromide)

Mepenzolate (bromide)

CAT N°: 23717
Price:

From 48.00 40.80

Mepenzolate is an antagonist of muscarinic (M) acetylcholine receptors (Kis = 0.68 and 2.6 nM for human M2 and M3 receptors, respectively).{41272} It has antispasmodic activity in the gastrointestinal tract of anesthetized cats and dogs when administered at a dose of 0.5 mg/kg.{41273} Mepenzolate decreases airspace enlargement induced by elastase or cigarette smoke and reduces respiratory dysfunction in a mouse model of chronic obstructive pulmonary disease (COPD).{41274} It also reduces oxidative stress, decreases the expression of IL-1?, IL-6, and TNF-?, and increases the expression of TGF-?1, IGF-1, and VEGF in a diabetic wound healing mouse model.{41275}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1,1-dimethyl-piperidinium, monobromide
  • Correlated keywords
    • 88215-34-3 Trancolon NSC4358 JB340 JB-340 Cantil Cantilaque Cantilon Cantril Colibantil Colopiril Colum Delevil Gastropidil Glycophenylate N-Methyl-3-piperidyl benzilate methyl bromide IGF1 IL6 IL1? TNF? TGF?1
  • Product Overview:
    Mepenzolate is an antagonist of muscarinic (M) acetylcholine receptors (Kis = 0.68 and 2.6 nM for human M2 and M3 receptors, respectively).{41272} It has antispasmodic activity in the gastrointestinal tract of anesthetized cats and dogs when administered at a dose of 0.5 mg/kg.{41273} Mepenzolate decreases airspace enlargement induced by elastase or cigarette smoke and reduces respiratory dysfunction in a mouse model of chronic obstructive pulmonary disease (COPD).{41274} It also reduces oxidative stress, decreases the expression of IL-1?, IL-6, and TNF-?, and increases the expression of TGF-?1, IGF-1, and VEGF in a diabetic wound healing mouse model.{41275}

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