MeOSuc-<wbr/>Ala-<wbr/>Ala-<wbr/>Pro-<wbr/>Val-<wbr/>AMC

MeOSuc-Ala-Ala-Pro-Val-AMC

CAT N°: 14907
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From 43.00 36.55

MeOSuc-Ala-Ala-Pro-Val-AMC (MeOSuc-AAPV-AMC) is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase. The methoxy succinyl (MeO-Suc) peptide AAPV is avidly hydrolyzed by these elastases but not by cathepsin G.{24237,23997} The addition of 7-amino-4-methylcoumarin (AMC) generates a peptide of low fluorescence (excitation: 355-380 nm; emission 440-460 nm) that demonstrates a linear increase in fluorescence in the presence of elastase.{24238} This peptidyl-AMC substrate detects as little as 11 pM human leukocyte elastase and 18 pM porcine pancreatic elastase.{24238}

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