Manzamine A

Manzamine A

CAT N°: 21444
Price:

From 237.00 201.45

Manzamine A is a ?-carboline alkaloid with diverse activities that has been found in marine sponges, including X. ashmorica.{42149} It is an inhibitor of glycogen synthase kinase 3? (GSK3?) and cyclin-dependent kinase 5 (CDK5; IC50s = 10.2 and 1.5 ?M, respectively).{42150} It inhibits the growth of L5178y mouse lymphoma cells with an ED50 value of 1.8 ?g/mL.{42149} In an agar diffusion assay, manzamine A inhibits the growth of B. subtilis and S. aureus, but not E. coli bacteria. It reduces the reverse transcriptase (RT) activity in supernatant from HIV-1-infected peripheral blood mononuclear cells (PBMCs; EC50 = 4.2 ?M).{42151} In vivo, manzamine A (100 ?mol/kg, i.p.) has antimalarial activity and reduces the amount of P. berghei in infected mice by over 90% relative to the control.{42152} Manzamine A (132 ppm) inhibits the growth of S. littoralis larva by 80% when added to the larval diet.{42149}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (1R,4S,9Z,13S,13aR,20aR,21aR)-2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-1,13-etheno-4,21a-methano-1H-azocino[1′,2′:1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol
  • Correlated keywords
    • Xestospongia GSK-3? CDK-5 L-5178y Bacillus Staphylococcus Escherichia HIV1 anti-malarial Plasmodium Spodoptera
  • Product Overview:
    Manzamine A is a ?-carboline alkaloid with diverse activities that has been found in marine sponges, including X. ashmorica.{42149} It is an inhibitor of glycogen synthase kinase 3? (GSK3?) and cyclin-dependent kinase 5 (CDK5; IC50s = 10.2 and 1.5 ?M, respectively).{42150} It inhibits the growth of L5178y mouse lymphoma cells with an ED50 value of 1.8 ?g/mL.{42149} In an agar diffusion assay, manzamine A inhibits the growth of B. subtilis and S. aureus, but not E. coli bacteria. It reduces the reverse transcriptase (RT) activity in supernatant from HIV-1-infected peripheral blood mononuclear cells (PBMCs; EC50 = 4.2 ?M).{42151} In vivo, manzamine A (100 ?mol/kg, i.p.) has antimalarial activity and reduces the amount of P. berghei in infected mice by over 90% relative to the control.{42152} Manzamine A (132 ppm) inhibits the growth of S. littoralis larva by 80% when added to the larval diet.{42149}

We also advise you