LY404039

LY404039

CAT N°: 18408
Price:

From 48.00 40.80

LY404039 is a potent agonist of metabotropic glutamate (mGlu) group II receptors mGluR2 and mGluR3 (Kis = 149 and 62 nM, respectively, for recombinant human isoforms).{32438} It displays 100-fold selectivity for mGluR2/3 over ionotropic glutamate receptors, glutamate transporters, and several other receptors targeted by known anxiolytic and antipsychotic medications.{32438} LY404039 inhibits the binding of domperidone (Item No. 18875) by 15.5% to dopamine D2 receptors (Kd = ~10 nM in vitro), indicating interaction with this receptor.{32439} LY404039 is orally bioavailable and demonstrates antipsychotic and anxiolytic efficacy in several animal models.{32437}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (1R,?4S,?5S,?6S)?-4-?amino-2-?thiabicyclo[3.1.0]?hexane-?4,?6-?dicarboxylic acid 2,?2-?dioxide
  • Correlated keywords
    • 191471-54-2 LY-404039 LY404040 LY-404040 LY-404,039 LY404,039 LY2140023 LY-2140023 human mGluR-2 mGluR-3 metabotropic glutamate receptor mGluR2 mGluR3 mGlu anxiolytic antipsychotic anti-psychotic domperidone dopamine pomaglumetad
  • Product Overview:
    LY404039 is a potent agonist of metabotropic glutamate (mGlu) group II receptors mGluR2 and mGluR3 (Kis = 149 and 62 nM, respectively, for recombinant human isoforms).{32438} It displays 100-fold selectivity for mGluR2/3 over ionotropic glutamate receptors, glutamate transporters, and several other receptors targeted by known anxiolytic and antipsychotic medications.{32438} LY404039 inhibits the binding of domperidone (Item No. 18875) by 15.5% to dopamine D2 receptors (Kd = ~10 nM in vitro), indicating interaction with this receptor.{32439} LY404039 is orally bioavailable and demonstrates antipsychotic and anxiolytic efficacy in several animal models.{32437}

We also advise you